Effects of Allulose vs Aspartame Consumption on Postprandial GLP-1 Profiles and Metabolic Health: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

Summary

Excessive sugar consumption is a public health concern. Allulose, a low-calorie sugar with similar functional properties to sucrose, offers potential metabolic benefits. Animal and limited human studies suggest it may stimulate GLP-1 secretion, improve glucose regulation, and support weight management. This randomized, double-blind, placebo-controlled, crossover trial in healthy adults assessed differences in postprandial GLP-1 profiles between acute intake of allulose and aspartame.

Key Findings

• Animal and limited human studies suggest it may stimulate GLP-1 secretion, improve glucose regulation, and support weight management.

Industry Relevance

This research reinforces allulose's metabolic benefits — supporting its positioning as a functional ingredient for blood glucose management, weight control, and metabolic health. For food and beverage manufacturers, these findings provide scientific substantiation for product claims related to glycemic response and appetite regulation.

Read the full paper: JMIR Research Protocols | DOI: 10.2196/81857